Suitability of a rapid immunochromatographic test for detection of antibodies to human immunodeficiency virus in Ghana, West Africa
Identifieur interne : 001125 ( Main/Exploration ); précédent : 001124; suivant : 001126Suitability of a rapid immunochromatographic test for detection of antibodies to human immunodeficiency virus in Ghana, West Africa
Auteurs : S. Aidoo [Ghana] ; W. K. Ampofo [Ghana] ; J. A. M. Brandful [Ghana] ; S. V. Nuvor [Ghana] ; J. K. Ansah [Ghana] ; N. Nii-Trebi [Ghana] ; J. S. Barnor [Ghana] ; F. Apeagyei [Ghana] ; T. Sata [Japon] ; D. Ofori-Adjei [Ghana] ; K. Ishikawa [Ghana, Japon]Source :
- Journal of clinical microbiology [ 0095-1137 ] ; 2001.
Descripteurs français
- KwdFr :
- Anticorps anti-VIH (sang), Chromatographie, Ghana, Humains, Immunotransfert (), Infections à VIH (diagnostic), Infections à VIH (virologie), Sensibilité et spécificité, Sérodiagnostic du SIDA (), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (immunologie).
- MESH :
- diagnostic : Infections à VIH.
- immunologie : VIH-1 (Virus de l'Immunodéficience Humaine de type 1), VIH-2 (Virus de l'Immunodéficience Humaine de type 2).
- sang : Anticorps anti-VIH.
- virologie : Infections à VIH.
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- AIDS Serodiagnosis (methods), Antibody, Chromatography, Detection, Ghana, HIV Antibodies (blood), HIV Infections (diagnosis), HIV Infections (virology), HIV-1 (immunology), HIV-2 (immunology), Human, Human immunodeficiency virus, Humans, Immune deficiency, Immunoblotting (methods), Sensitivity and Specificity, West Africa.
- MESH :
- chemical , blood : HIV Antibodies.
- geographic : Ghana.
- diagnosis : HIV Infections.
- immunology : HIV-1, HIV-2.
- methods : AIDS Serodiagnosis, Immunoblotting.
- virology : HIV Infections.
- Chromatography, Humans, Sensitivity and Specificity.
Abstract
In West African countries such as Ghana, efficient human immunodeficiency virus (HIV) testing is a priority in the fight against AIDS. A new immunochromatographic rapid test, Determine HIV-1/2 (Abbott Diagnostics, North Chicago, Ill.), that detects antibodies against HIV type 1 (HIV-1) and/or HIV-2 was evaluated using Ghanaian blood samples. Two hundred four serum and/or plasma specimens were tested. HIV screening was done by a particle agglutination test and confirmed by a Western blot (WB) test as the "gold standard." The results revealed 125 HIV-seropositive AIDS patients, 75 HIV-seronegative healthy individuals, and 4 individuals for whom the HIV-1 result was indeterminate. The results obtained by the Determine HIV-1/2 assay and Diagnostic HIV SPOT (Genelabs), which is currently widely used in many districts in Ghana, were compared with those of the WB test, excluding the four HIV-1-indeterminate samples. The sensitivity of the Determine HIV-1/2 assay was 100%, compared with 98.0% for the HIV SPOT assay. The specificity was 100% for both tests. Determine HIV-1/2 is a single-step assay and was found to be rapid and easy to perform without any special equipment. It was highly sensitive and specific. The kit can be applied without electricity and water supplies, making it suitable for the detection of HIV antibodies especially in the rural areas of Ghana, West Africa.
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Le document en format XML
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Aidoo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Noguchi Memorial Institute for Medical Research, University of Ghana</s1><s2>Accra</s2><s3>GHA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Ampofo, W K" sort="Ampofo, W K" uniqKey="Ampofo W" first="W. K." last="Ampofo">W. K. Ampofo</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Noguchi Memorial Institute for Medical Research, University of Ghana</s1><s2>Accra</s2><s3>GHA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Brandful, J A M" sort="Brandful, J A M" uniqKey="Brandful J" first="J. A. M." last="Brandful">J. A. M. Brandful</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Noguchi Memorial Institute for Medical Research, University of Ghana</s1><s2>Accra</s2><s3>GHA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Nuvor, S V" sort="Nuvor, S V" uniqKey="Nuvor S" first="S. V." last="Nuvor">S. V. Nuvor</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Noguchi Memorial Institute for Medical Research, University of Ghana</s1><s2>Accra</s2><s3>GHA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Ansah, J K" sort="Ansah, J K" uniqKey="Ansah J" first="J. K." last="Ansah">J. K. Ansah</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Blood Transfusion Service, Ministry of Health</s1><s2>Korle-Bu</s2><s3>GHA</s3><sZ>5 aut.</sZ></inist:fA14><country>Ghana</country><wicri:noRegion>Korle-Bu</wicri:noRegion></affiliation></author><author><name sortKey="Nii Trebi, N" sort="Nii Trebi, N" uniqKey="Nii Trebi N" first="N." last="Nii-Trebi">N. Nii-Trebi</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Noguchi Memorial Institute for Medical Research, University of Ghana</s1><s2>Accra</s2><s3>GHA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Barnor, J S" sort="Barnor, J S" uniqKey="Barnor J" first="J. S." last="Barnor">J. S. Barnor</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Noguchi Memorial Institute for Medical Research, University of Ghana</s1><s2>Accra</s2><s3>GHA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Apeagyei, F" sort="Apeagyei, F" uniqKey="Apeagyei F" first="F." last="Apeagyei">F. Apeagyei</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Hygiene Wing, Military Hospital</s1><s2>Accra</s2><s3>GHA</s3><sZ>8 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName></affiliation></author><author><name sortKey="Sata, T" sort="Sata, T" uniqKey="Sata T" first="T." last="Sata">T. Sata</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>National Institute of Infectious Diseases</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Ofori Adjei, D" sort="Ofori Adjei, D" uniqKey="Ofori Adjei D" first="D." last="Ofori-Adjei">D. Ofori-Adjei</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Noguchi Memorial Institute for Medical Research, University of Ghana</s1><s2>Accra</s2><s3>GHA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation></author><author><name sortKey="Ishikawa, K" sort="Ishikawa, K" uniqKey="Ishikawa K" first="K." last="Ishikawa">K. Ishikawa</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Noguchi Memorial Institute for Medical Research, University of Ghana</s1><s2>Accra</s2><s3>GHA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Ghana</country><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Ghana</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>National Institute of Infectious Diseases</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of clinical microbiology</title><title level="j" type="abbreviated">J. clin. microbiol.</title><idno type="ISSN">0095-1137</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of clinical microbiology</title><title level="j" type="abbreviated">J. clin. microbiol.</title><idno type="ISSN">0095-1137</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS Serodiagnosis (methods)</term><term>Antibody</term><term>Chromatography</term><term>Detection</term><term>Ghana</term><term>HIV Antibodies (blood)</term><term>HIV Infections (diagnosis)</term><term>HIV Infections (virology)</term><term>HIV-1 (immunology)</term><term>HIV-2 (immunology)</term><term>Human</term><term>Human immunodeficiency virus</term><term>Humans</term><term>Immune deficiency</term><term>Immunoblotting (methods)</term><term>Sensitivity and Specificity</term><term>West Africa</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps anti-VIH (sang)</term><term>Chromatographie</term><term>Ghana</term><term>Humains</term><term>Immunotransfert ()</term><term>Infections à VIH (diagnostic)</term><term>Infections à VIH (virologie)</term><term>Sensibilité et spécificité</term><term>Sérodiagnostic du SIDA ()</term><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie)</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2) (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>HIV Antibodies</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Ghana</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>VIH-1 (Virus de l'Immunodéficience Humaine de type 1)</term><term>VIH-2 (Virus de l'Immunodéficience Humaine de type 2)</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>HIV-1</term><term>HIV-2</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>AIDS Serodiagnosis</term><term>Immunoblotting</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps anti-VIH</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à VIH</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>HIV Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Chromatography</term><term>Humans</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chromatographie</term><term>Ghana</term><term>Homme</term><term>Humains</term><term>Immunotransfert</term><term>Sensibilité et spécificité</term><term>Sérodiagnostic du SIDA</term><term>Virus immunodéficience humaine</term><term>Détection</term><term>Anticorps</term><term>Ghana</term><term>Afrique Ouest</term><term>Immunodéficit</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Ghana</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In West African countries such as Ghana, efficient human immunodeficiency virus (HIV) testing is a priority in the fight against AIDS. A new immunochromatographic rapid test, Determine HIV-1/2 (Abbott Diagnostics, North Chicago, Ill.), that detects antibodies against HIV type 1 (HIV-1) and/or HIV-2 was evaluated using Ghanaian blood samples. Two hundred four serum and/or plasma specimens were tested. HIV screening was done by a particle agglutination test and confirmed by a Western blot (WB) test as the "gold standard." The results revealed 125 HIV-seropositive AIDS patients, 75 HIV-seronegative healthy individuals, and 4 individuals for whom the HIV-1 result was indeterminate. The results obtained by the Determine HIV-1/2 assay and Diagnostic HIV SPOT (Genelabs), which is currently widely used in many districts in Ghana, were compared with those of the WB test, excluding the four HIV-1-indeterminate samples. The sensitivity of the Determine HIV-1/2 assay was 100%, compared with 98.0% for the HIV SPOT assay. The specificity was 100% for both tests. Determine HIV-1/2 is a single-step assay and was found to be rapid and easy to perform without any special equipment. It was highly sensitive and specific. The kit can be applied without electricity and water supplies, making it suitable for the detection of HIV antibodies especially in the rural areas of Ghana, West Africa.</div></front></TEI><affiliations><list><country><li>Ghana</li><li>Japon</li></country><region><li>Région de Kantō</li><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Tokyo</li></settlement><orgName><li>Université du Ghana</li></orgName></list><tree><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Aidoo, S" sort="Aidoo, S" uniqKey="Aidoo S" first="S." last="Aidoo">S. Aidoo</name></region><name sortKey="Ampofo, W K" sort="Ampofo, W K" uniqKey="Ampofo W" first="W. K." last="Ampofo">W. K. Ampofo</name><name sortKey="Ansah, J K" sort="Ansah, J K" uniqKey="Ansah J" first="J. K." last="Ansah">J. K. Ansah</name><name sortKey="Apeagyei, F" sort="Apeagyei, F" uniqKey="Apeagyei F" first="F." last="Apeagyei">F. Apeagyei</name><name sortKey="Barnor, J S" sort="Barnor, J S" uniqKey="Barnor J" first="J. S." last="Barnor">J. S. Barnor</name><name sortKey="Brandful, J A M" sort="Brandful, J A M" uniqKey="Brandful J" first="J. A. M." last="Brandful">J. A. M. Brandful</name><name sortKey="Ishikawa, K" sort="Ishikawa, K" uniqKey="Ishikawa K" first="K." last="Ishikawa">K. Ishikawa</name><name sortKey="Nii Trebi, N" sort="Nii Trebi, N" uniqKey="Nii Trebi N" first="N." last="Nii-Trebi">N. Nii-Trebi</name><name sortKey="Nuvor, S V" sort="Nuvor, S V" uniqKey="Nuvor S" first="S. V." last="Nuvor">S. V. Nuvor</name><name sortKey="Ofori Adjei, D" sort="Ofori Adjei, D" uniqKey="Ofori Adjei D" first="D." last="Ofori-Adjei">D. Ofori-Adjei</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Sata, T" sort="Sata, T" uniqKey="Sata T" first="T." last="Sata">T. Sata</name></region><name sortKey="Ishikawa, K" sort="Ishikawa, K" uniqKey="Ishikawa K" first="K." last="Ishikawa">K. Ishikawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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